CRDA: Inflammatory Marker Outcomes (2023)

Author and Year:
Marin-Alejandre B, Abete I, Cantero I, et al. 2019
PubMed ID:
Article Title:
The Metabolic and Hepatic Impact of Two Personalized Dietary Strategies in Subjects with Obesity and Nonalcoholic Fatty Liver Disease: The Fatty Liver in Obesity (FLiO) Randomized Controlled Trial.
Marin-Alejandre B, Abete I, Cantero I, Monreal J, Elorz M,Herrero J, Benito-Boillos A, Quiroga J, Martinez-Echeverria A, Uriz-Otano J, Huarte-Muniesa M,T ur J, Martinez J, Zulet M
Year of publication:
Page numbers:
Study Design:
Randomized Controlled Trial
Risk of Bias Assessment Rating:
Low risk
Inclusion Criteria:
Overweight or obese (BMI >/= 27.5 kg/m2 to < 40 kg/m2); 40-80 years old; hepatic steatosis confirmed by abdominal ultrasonography.
Exclusion Criteria:
Presence of known liver disease other than NAFLD; >/= 3 kg of body weight loss in the last 3 months; excessive alcohol consumption (>21 and >14 units of alcohol per week for men and women, respectively); endocrine disorders (hyperthyroidism or uncontrolled hypothyroidism); pharmacological treatment with immunosuppressants, cytotoxic agents, systemic corticosteroids (or other drugs that could potentially cause hepatic steatosis or altering liver tests); active autoimmune diseases or requiring pharmacological treatment; use of weight modifiers; severe psychiatric disorders; lack of autonomy or an inability to follow the diet; difficulties in following the scheduled visits.
Research Purpose:
To evaluate the effects of two personalized energy-restricted dietary strategies differing in several dietary factors (macronutrients, fiber, meal frequency, total antioxidant capacity, and Mediterranean diet adherence) on liver status, as assessed by imaging techniques and biochemical markers in overweight and obese subjects with NAFLD after a 6 months follow-up.
Blinding efforts:
Study Location:
Source(s) of Funding:
Government, Foundation
Please specify names of funders:
Health Department of the Government of Navarra, CIBERobn (Physiopathology of Obesity and Nutrition), Fundació La Marató de TV3, Principal author was supported by fellowships from Consejo Nacional de Ciencia y Tecnología (CONACYT) y el Estado de Michoacán