CRDA: Lipid Outcomes (2023)
Author and Year:
Chen C, Huang W, et al, 2020
PubMed ID:
Article Title:
Effect of a 90 g/day low-carbohydrate diet on glycaemic control, small, dense low-density lipoprotein and carotid intima-media thickness in type 2 diabetic patients: An 18-month randomised controlled trial.
Authors:
Chen C, Huang W, Chen H, Chang C, Lee L, Chen H, Kang Y, Chie W, Jan C, Wang W, Tsai J
Journal:
PloS One
Year of publication:
2020
Volume:
15
Issue:
10
Page numbers:
e0240158
Study Design:
Randomized Controlled Trial
Risk of Bias Assessment Rating:
Some concerns
Inclusion Criteria:
Adults aged 20-80 years; type 2 diabetes mellitus diagnosis for more than 1 year; poorly controlled HbA1c >/= 58 mol/mol (7.5%) in the previous three months regardless of medication.
Exclusion Criteria:
Pregnant or lactating women; impaired renal function with serum creatinine >/= 132.6 umol/L (1.5 mg/dL);
Abnormal liver function (alanine aminotransferase (ALT), aspartame aminotransferase >/= 3 times the normal upper limit; liver cirrhosis; significant heart diseases (unstable angina, unstable heart failure);
Frequent gout attacks (>/= 3 times/year); participation in other weight loss programs or use of weight loss drugs; eating disorders; inability to complete the questionnaire.
Research Purpose:
To explore the effect of a moderate (90 g/d) low carbohydrate diet (LCD) in type 2 diabetes patients over 18 months.
Blinding efforts:
A blind evaluator calculated calorie and nutrition intake from three day weighted food records.
Study Location:
National Taiwan University Hospital, Taipei, Taiwan
Source(s) of Funding:
University/Hospital
Please specify names of funders:
National Taiwan University Hospital