CRDA: Lipid Outcomes (2023)

Author and Year:
Haufe S, Engeli S, et al. 2011
PubMed ID:
Article Title:
Randomized comparison of reduced fat and reduced carbohydrate hypocaloric diets on intrahepatic fat in overweight and obese human subjects.
Haufe S, Engeli S, Kast P, Böhnke J, Utz W, Haas V, Hermsdorf M, Mähler A, Wiesner S, Birkenfeld A, Sell H, Otto C, Mehling H, Luft F, Eckel J, Schulz-Menger J, Boschmann M, Jordan J
Hepatology (Baltimore, MD)
Year of publication:
Page numbers:
Study Design:
Randomized Controlled Trial
Risk of Bias Assessment Rating:
Inclusion Criteria:
Men and women; overweight and obese but otherwise healthy; no ingested medications.
Exclusion Criteria:
Subjects reporting more than 2 hours of physical activity per week; subjects consuming >20 g/day of alcohol; diagnosed with type 2 diabetes, acute or chronic infections, any diseases requiring treatment; pregnant or nursing women.
Research Purpose:
To determine whether or not a reduced carbohydrate diet is as effective in reducing hepatic lipid content in obese individuals as a low-fat hypocaloric diet.
Blinding efforts:
Except for the dieticians, study nurses and physicians were blinded for the treatment assignment.
Study Location:
Source(s) of Funding:
Please specify names of funders:
Federal Ministry of Education and Research (BMBF-0313868) and in part by the Commission of the European Communities (Collaborative Project ADAPT,Contract No. HEALTH-F2-2008-201100) and the German Obesity Network of Competence (Collaborative Project ADIPOSETARGET, 01 Gl0830) (to S.E. andJ.J). Clinical trial number: NCT00956566