Fechner E, Bilet L, et al. 2020

31899037

Effects of a whole diet approach on metabolic flexibility, insulin sensitivity and postprandial glucose responses in overweight and obese adults - A randomized controlled trial.

Fechner E, Bilet L, Peters H, Hiemstra H, Jacobs D, Op 't Eyndt C, Kornips E, Mensink R, Schrauwen P

Clinical Nutrition

2020

39

9

2734-2742

Randomized Controlled Trial

Some concerns

Age 50-70 years old; healthy; overweight or obese (BMI 25-35 kg/m2)

Any medical condition which might have affected the study measurements, i.e. metabolic disorders, including type 1 and type 2 diabetes, gastrointestinal dysfunction, gastrointestinal surgery or inflammatory diseases); fasting plasma glucose of >6.9 mmol/l; smoking' shift work; excessive alcohol consumption (>7 consumptions per week); medically prescribed diets; slimming diets' being vegetarian; doing more than 2.5 hours of moderate to vigorous physical activity per week; reported weight loss or gain of >10% in the past 6 months; medication which could have interfered with the study measurements.

To assess the effect of a healthy diet, as compared to a typical Western diet, on several fasting and postprandial markers of metabolic flexibility and insulin sensitivity

The Netherlands

Industry

Unilever Food Innovation Center