Meroni A, Muirhead R, et al. 2020

33365325

Is a Higher Protein-Lower Glycemic Index Diet More Nutritious Than a Conventional Diet? A PREVIEW Sub-study.

Meroni A, Muirhead R, Atkinson F, Fogelholm M, Raben A, Brand-Miller J

Frontiers in Nutrition

2020

7

603801

Randomized Controlled Trial

Some concerns

Adult men and women; age 25 - 70 years: from mid 2013 - mid 2014, subjects aged 25-45 and 55-70 years were enrolled. From mid 2014, subjects aged 46-54 years were also enrolled. BMI greater than 25. Pre-diabetes: Impaired Fasting Glucose (IFG): Fasting venous plasma glucose concentration 5.6 - 6.9 mmol/l or Impaired Glucose Tolerance (IGT): Venous Plasma glucose concentration of 7.8 - 11.0 mmol/l at 2 h after oral administration of 75 g glucose (oral glucose tolerance test, OGTT), with fasting plasma glucose less than 7.0 mmol/l. Loss of 8% or greater of initial body weight to be eligible for weight maintenance phase. Informed consent.

Diabetes mellitus (other than gestational diabetes mellitus); self-reported weight change of >5 % (increase or decrease) within 2 months prior to screening; significant liver disease e.g. cirrhosis (fatty liver disease allowed); failure to reach at least 8% weight reduction during the LCD phase. This leads to exclusion from the intervention.

To compare the changes in nutrient intakes of individuals at high risk of developing type-2 diabetes over 3 years who followed either a higher protein-lower GI diet (HPLG) or a conventional moderate protein-moderate GI diet (MPMG). We hypothesized that a healthy HPLG dietary intervention would be associated with more positive changes in micronutrient density than a healthy MPMG dietary intervention.

Australia

Government, University/Hospital

National Health and Medical Research Council-EU Collaborative grant, Glycemic Index Foundation Australia through royalties to the University of Sydney, University of Sydney. See extensive list of founders for PREVIEW in reviewers comments.