CRDA: Lipid Outcomes (2023)

Author and Year:
de Melo C, Dos Santos Quaresma M, et al. 2021
PubMed ID:
Article Title:
One-month of a low-energy diet, with no additional effect of high-protein, reduces Obstructive Sleep Apnea severity and improve metabolic parameters in obese males.
de Melo C, Dos Santos Quaresma M, Del Re M, Ribeiro S, Moreira Antunes H, Togeiro S, Tufik S, de Mello M
Clinical Nutrition ESPEN
Year of publication:
Page numbers:
Study Design:
Randomized Controlled Trial
Risk of Bias Assessment Rating:
Some concerns
Inclusion Criteria:
Male; 30-55 years old; obstructive sleep apnea diagnosed by polysomnography.
Exclusion Criteria:
Age <30 and >55 years; mild sleep apnea severity (AHI <5 events/hour); use of any other obstructive sleep apnea treatment such as CPAP, drugs or oral appliance therapy; using drugs for metabolic diseases such as diabetes mellitus, dyslipidemia, or thyroid diseases; shift workers; other sleep disturbances rather than/in addition to OSA; smoking; physical exercise practitioners; individuals with eating disorders; physical exercise practitioners
Research Purpose:
To evaluate the effects of a low-energy, high-protein diet on obese men's OSA (Obstructive Sleep Apnea) severity and metabolic parameters. We tested the hypothesis that increased protein intake during an energy-restricted diet results in better OSA and metabolic improvements due to increased energy expenditure and fat/fat-free mass relation than a normal-protein-content diet in OSA patients.
Blinding efforts:
Not reported
Study Location:
Sao Paulo, Brazil
Source(s) of Funding:
Please specify names of funders:
Associaçao Fundo de Incentivo?a Pesquisa (AFIP), Centro de Estudos em Psicobiologia e Exercício(CEPE), CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnologico), CAPES (Coordenaçao de Aperfeiçoamento Pessoal de Nível Superior), FAPESP (Fundaçao de Amparo?a pesquisa do Estadode Sao Paulo) Grant number: 2012/09700-2