Haslam R, Bezzina A, et al, 2021

34574879

Can Ketogenic Diet Therapy Improve Migraine Frequency, Severity and Duration?

Haslam R, Bezzina A, Herbert J, Spratt N, Rollo M, Collins C

Healthcare (Basel, Switzerland)

2021

9

9

Randomized Crossover Trial

High

Any gender; aged 18 and over; history of migraine headaches consisting of at least two episodes of moderate intensity (or greater) or at least five episodes of mildly intense headache in the previous four weeks with >/= 50% of headache days being migraine or probable migraine days.

Diagnosed with any neurological condition (e.g. epilepsy or mental trauma); medical condition requiring specific medical nutrition therapy (e.g. diabetes or celiac disease); history of strokes; have a pacemaker; currently taking medications contraindicated whilst on ketogenic diet therapy (KDT) (e.g. blood pressure medication or insulin); pregnant or breastfeeding; not proficient in the English language; have an intellectual or mental impairment where decision-making capacity is compromised; do not own a smartphone; have any of the following conditions: gallbladder disease or removal of gallbladder, had bariatric surgery, pancreatic insufficiency, liver disease, history of kidney stones, eating disorder.

To investigate whether the ketogenic diet therapy (KDT) is superior to an evidence-informed healthy "anti-headache" dietary pattern (AHD) in improving migraine frequency, severity and duration.

The researcher who randomized the participants had no contact with participants during the trial.

The University of Newcastle, Callaghan, Australia

Government, University/Hospital, Community

Hunter Medical Research Institute, National Health and Medical Research Council Senior Research Fellowship, University of Newcastle Faculty of Health and Medicine Gladys M. Brawn Senior Research Fellowship