CRDA: Other Outcomes (2023)

Author and Year:
Knight A, Bryan J, et al. 2016
PubMed ID:
Article Title:
The Mediterranean Diet and Cognitive Function among Healthy Older Adults in a 6-Month Randomised Controlled Trial: The MedLey Study.
Knight A, Bryan J, Wilson C, Hodgson J, Davis C, Murphy K
Year of publication:
Page numbers:
Study Design:
Randomized Controlled Trial
Risk of Bias Assessment Rating:
Some concerns
Inclusion Criteria:
>/= 65 years old; normal cognitive function; proficient in English; weight less than 135 kg
Exclusion Criteria:
Previous or current conditions that may cause any kind of cognitive impairment, such as a traumatic head/brain injury, stroke; suffering a neurological or psychiatric condition; using medications known to influence cognition; cardiovascular disease or angina, uncontrolled hypertension (>170/100), malignancy, any major liver, kidney, respiratory or gastrointestinal disease; actively undertaking a weight loss program; smoking; using any form of appetite suppressant or Orlistat (Xenical); participating in any other dietary intervention study
Research Purpose:
To comprehensively examine the effects of a MedDiet pattern versus a habitual dietary pattern on various neuropsychological tests as well as five composite variables including: Overall age-related cognitive function, speed of processing, memory, executive functioning, visual spatial ability among healthy older adult participants (?65 years) in a six-month randomised intervention trial, using a wide-ranging test battery that was selected based on sensitivity to dietary change over six months
Blinding efforts:
Study Location:
Source(s) of Funding:
Please specify names of funders:
National Health Medical Research Council (NHMRC)