CRDA: Inflammatory Marker Outcomes (2023)

Author and Year:
Lim S, Noakes M, et al. 2010
PubMed ID:
Article Title:
Long-term effects of a low carbohydrate, low fat or high unsaturated fat diet compared to a no-intervention control.
Lim S, Noakes M, Keogh J, Clifton P
Nutrition, Metabolism, and Cardiovascular Diseases
Year of publication:
Page numbers:
Study Design:
Randomized Controlled Trial
Risk of Bias Assessment Rating:
Inclusion Criteria:
Aged between 20 and 65 years; at least one CVD risk factor other than obesity; BMI between 28 and 40 kg/m2; maintain stable doses of beta-blockers, fish oil supplements, cholesterol-lowering agents, prednisolone, steroids and diuretics; written informed consent.
Exclusion Criteria:
Use of hypoglycemic medication or drugs that affect insulin sensitivity; history of heavy alcohol consumption; history of metabolic or coronary heart disease, type 1 or type 2 diabetes, widely fluctuating exercise patterns and frequent dining out (>2 per week and unable to cease).
Research Purpose:
The primary objective of this study was to compare the long-term effects of three energy reduced, isocaloric diets, which is the very low carbohydrate (VLC) diet, very low fat (VLF) diet and high unsaturated fat (HUF) diet on weight loss and cardiovascular risk factors in a 15-month randomized controlled trial in overweight or obese individuals with elevated cardiovascular risks. The secondary purpose of this study was to determine if these diets would result in significantly different effects compared to a no-intervention control after 15 months.
Blinding efforts:
Study Location:
Adelaide, Australia
Source(s) of Funding:
Government, Other
Please specify names of funders:
National Heart Foundation, Australia; CSIRO Health Sciences and Nutrition, Adelaide, Australia