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Preterm Infant (VLBW) Enteral Nutrition

Preterm Infant (VLBW) Enteral Nutrition Systematic Review (2017-2020)

Very Low Birthweight Preterm Term Infants Enteral Nutrition Systematic Review
The expert workgroup focused on very low preterm term infants (≤1,500 grams birth weight) and on these sub-topic areas:

  • Macronutrients
    • Breast Milk Fortifier Type
    • Breast Milk Fortifiers
    • Formula Enrichment
    • Pasteurization
    • Protein Amount
    • Protein-Energy
    • Type of Fat
    • Type of Protein
    • Non-Protein Energy
  • Human Milk vs. Formula
    • Mothers’ Milk vs. Exclusive Formula
    • Mothers' Milk Dose Response
    • Supplementation of Mothers’ Milk with Donor Milk
    • Human Milk (Mothers’ Milk and Donor) vs. Exclusive Formula
    • Human Milk (Mother’s milk and Donor) Dose Response
    • Donor Milk vs. Exclusive Formula

Key Findings:

  • Infants fed human milk should be enriched with multi-nutrient fortifiers
  • Infants should be fed with 3.5-4.0 g protein/kg/day
  • Evidence is lacking that supplementation with omega 3 fatty acid influences health outcomes
  • Infants fed ≥75% mothers’ own milk compared to formula is associated with lower incidence of retinopathy of prematurity
  • There is evidence of a positive dose response relationship between mothers’ own milk and development, a negative dose response between mothers’ own milk and sepsis
  • When mothers’ own milk is lacking infants should be provided with pasteurized donor milk

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