T1DM: Vitamin D Supplementation (2023)

Intervention
In children and adolescents (6-19 years old) living with type 1 diabetes, what is the effect of vitamin D supplementation compared to no supplementation on A1C?
- Conclusion
  In children and adolescents (6-19 years old) living with type 1 diabetes mellitus, vitamin D insufficiency (defined as serum 25-hydroxyvitamin D [25(OH)D] concentrations of 30 - 50 nmol/L or 12 - 20 ng/mL) and/or deficiency (defined as serum 25-hydroxyvitamin D [25(OH)D] concentrations of <30 nmol/L or <12 ng/mL) are common, affecting as many as 63% of patients. Vitamin D supplementation repletes vitamin deficiency, but its effect on A1C is inconclusive.
- Grade: Low (C)
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In children and adolescents (6-19 years old) living with type 1 diabetes, what is the effect of vitamin D supplementation compared to no supplementation on A1C?
- Search Plan and Results: T1DM: Interventions 2023