Anton S, Manini T, et al, 2011

21753869

Effects of a weight loss plus exercise program on physical function in overweight, older women: a randomized controlled trial.

Anton S, Manini T, Milsom V, Dubyak P, Cesari M, Cheng J, Daniels M, Marsiske M, Pahor M, Leeuwenburgh C, Perri M

Clinical Interventions in Aging

2011

6

141-149

Randomized Controlled Trial

Some concerns

Age between 55 years and 79 years; BMI >28 kg/m2; sedentary lifestyle (defined as <20 min/week of aerobic exercise; mild to moderate impairment on the Short Physical Performance Battery (SPPB; scores 4–10); agree to maintain their usual physical activity patterns and not to initiate any new exercise other than that associated with their randomly assigned treatment condition over the course of the study.

Participating in another research project; weight >136.1 kg; weight loss >4.5 kg in the past 6 months; history of surgery for weight loss; hospitalization within the past 6 months; coronary heart disease; chronic or recurrent respiratory or gastrointestinal conditions; cancer [except nonmelanoma skin cancer] within 5 years; fasting blood glucose >110 mg/dL; resting blood pressure >160/90 mmHg; bone, muscle, or joint conditions that would prevent walking on a regular basis; taking antipsychotic agents, monoamine oxidase inhibitors, systemic corticosteroids, antibiotics for HIV or tuberculosis, chemotherapeutic drugs; current use of prescription weight loss drugs

To test whether a weight loss program combined with moderate exercise could improve physical function in obese, older adult women

FL, United States

Government, Not-for-profit

National Institutes of Health-Funded Claude D Pepper Older Americans Independence Center (P30AG028740) Stephen Anton is supported by a K23 AT004251-01A2, an Early Career Investigator Award from the American Heart Association and the Thomas H Maren Foundation