Diabetes Type 1 and 2

DM: Protein Amount (2014)

• Intervention
  In adults with type 1 and type 2 diabetes, what is the relationship of differing amounts of protein, independent of weight loss, on diabetic kidney disease (GFR and/or proteinuria)?

  • Conclusion
    Research reports that the amount of protein (ranging from 0.7g to 2.0g per kg per day) had no effect on glomerular filtration rate (GFR), independent of weight loss, in adults with type 1 and type 2 diabetes and diabetic kidney disease (DKD). No studies reported on proteinuria.
  • Grade: I
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: In adults with type 1 and type 2 diabetes, what is the relationship of differing amounts of protein, independent of weight loss, on diabetic kidney disease (GFR and proteinuria)?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Robertson L, Waugh N, Robertson A. Protein restriction for diabetic renal disease. Cochrane Database Syst Rev. 2007; 4: CD002181.
      • Velázquez LL, Sil AMJ, Goycochea RMV, Torres TM, Castañeda LR. Effect of protein restriction diet on renal function and metabolic control in patients with type 2 diabetes: A randomized clinical trial. Nutr Hosp. 2008; 23: 141-147.
  • Search Plan and Results: DM: Protein Amount 2013
     
  In adults with type 1 and type 2 diabetes, what is the relationship of differing amounts of protein, independent of weight loss, on glycemia (A1C or glucose)?

  • Conclusion
    Research reports mixed results regarding the effects of the amount of protein (ranging from 0.8g to 2.0g per kg per day) on fasting glucose levels and A1C, independent of weight loss, in adults with type 1 and type 2 diabetes and diabetic kidney disease (DKD).
  • Grade: III
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: In adults with type 1 and type 2 diabetes, what is the relationship of differing amounts of protein, independent of weight loss, on glycemia (A1C and glucose)?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Hansen HP, Tauber-Lassen E, Jensen BR, Parving H-H. Effect of dietary protein restriction on prognosis in patients with diabetic nephropathy.  Kidney Int 2002:61:220-228.
      • Raal FJ, Kalk WJ, Lawson M, Esser JD, Buys R, Fourie L, Panz VR. Effect of moderate dietary protein restriction on the progression of overt diabetic nephropathy: a 6-month prospective study. Am J Clin Nutr. 1994;60:579-585.
      • Velázquez LL, Sil AMJ, Goycochea RMV, Torres TM, Castañeda LR. Effect of protein restriction diet on renal function and metabolic control in patients with type 2 diabetes: A randomized clinical trial. Nutr Hosp. 2008; 23: 141-147.
  • Search Plan and Results: DM: Protein Amount 2013
     
  In adults with type 1 and type 2 diabetes, what is the relationship of differing amounts of protein, independent of weight loss, on insulin levels (exogenous/endogenous)?

  • Conclusion

    There were no studies identified regarding the relationship of differing amounts of protein, independent of weight loss, on insulin levels (exogenous or endogenous) in adults with type 1 and type 2 diabetes.

    Intervention studies are needed regarding the impact of differing amounts of protein on insulin levels in adults with diabetes.

  • Grade: V
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Search Plan and Results: DM: Protein Amount 2013