DM: Types of Protein (Vegetable-Based vs. Animal-Based)

Intervention
In adults with type 1 and type 2 diabetes, what is the relationship of differing types of protein (vegetable-based versus animal-based), independent of weight loss, on diabetic kidney disease (GFR and/or proteinuria)?
- Conclusion
  One study reports a positive impact of soy protein compared to animal protein on proteinuria, independent of weight loss, in adults with type 2 diabetes and diabetic kidney disease (DKD). There was no significant impact of soy protein consumption on glomerular filtration rate. There were no studies identified in adults with type 1 diabetes.
  
  Additional intervention studies are needed regarding the impact of differing types of protein on diabetic kidney disease in adults with diabetes.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In adults with type 1 and type 2 diabetes, what is the relationship of differing types of protein (vegetable-based vs. animal-based), independent of weight loss, on diabetic kidney disease (GFR and proteinuria)?
  - Detail
  - Quality Rating Summary
    For a summary of the Quality Rating results, click here.
  - Worksheets
    
    Azadbakht L, Atabak S, Esmaillzadeh A. Soy protein intake, cardiorenal indices, and C-reactive protein in type 2 diabetes with nephropathy: a longitudinal randomized clinical trial. Diabetes Care. 2008; 31(4): 648-654.
- Search Plan and Results: DM: Type of Protein 2013
In adults with type 1 and type 2 diabetes, what is the relationship of differing types of protein (vegetable-based vs. animal-based), independent of weight loss, on glycemia (A1C or glucose)?
- Conclusion
  One study reports a positive impact of soy protein compared to animal protein on fasting glucose levels, independent of weight loss, in adults with type 2 diabetes and diabetic kidney disease (DKD). No studies were identified that reported on A1C or that included adults with type 1 diabetes.
  
  Additional intervention studies are needed regarding the impact of differing types of protein on glycemia in adults with diabetes.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In adults with type 1 and type 2 diabetes, what is the relationship of differing types of protein (vegetable-based vs. animal-based), independent of weight loss, on glycemia (A1C and glucose)?
  - Detail
  - Quality Rating Summary
    For a summary of the Quality Rating results, click here.
  - Worksheets
    
    Azadbakht L, Atabak S, Esmaillzadeh A. Soy protein intake, cardiorenal indices, and C-reactive protein in type 2 diabetes with nephropathy: a longitudinal randomized clinical trial. Diabetes Care. 2008; 31(4): 648-654.
- Search Plan and Results: DM: Type of Protein 2013
In adults with type 1 and type 2 diabetes, what is the relationship of differing types of protein (vegetable-based versus animal-based), independent of weight loss, on insulin levels (exogenous/endogenous)?
- Conclusion
  There were no studies identified regarding the relationship of differing types of protein (vegetable-based versus animal-based), independent of weight loss, on insulin levels (exogenous/endogenous) in adults with type 1 and type 2 diabetes.
  
  Intervention studies are needed regarding the impact of differing types of protein on insulin levels in adults with diabetes.
- Grade: V
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Search Plan and Results: DM: Type of Protein 2013