AWM: Weight Management Interventions Provided by Dietitians for Older Adults (2021)

Author and Year:
Colleluoir G, Aguirre L, et al, 2020
PubMed ID:
Article Title:
Aerobic plus resistance exercise in obese older adults improves muscle protein synthesis and preserves myocellular quality despite weight loss.
Colleluori G, Aguirre L, Phadnis U, Fowler K, Armamento-Villareal R, Sun Z, Brunetti L, Hyoung Park J, Kaipparettu B, Putluri N, Auetumrongsawat V, Yarasheski K, Qualls C, Villareal D
Cell Metabolism
Year of publication:
Page numbers:
Study Design:
Randomized Controlled Trial
Risk of Bias Assessment Rating:
Some concerns
Inclusion Criteria:
Age >/= 65 years, BMI >/= 30 kg/m2, sedentary lifestyle, stable body weight for six months before enrollment, mild to moderate frailty.
Exclusion Criteria:
Severe cardiopulmonary disease, musculoskeletal or neuromuscular impairments that precluded exercise training or cognitive impairment.
Research Purpose:
To compare the chronic (6 month) effects of weight loss plus aerobic or resistance or the combination of both exercise modalities on changes in 1) muscle protein synthesis MPS response to feeding, 2) expression of regulators of myocellular quality (e.g. proteostasis, mitochondrial function, myogenesis, and inflammation) and 3) circulating C-terminal agrin fragment (CAF), a marker of neuromuscular junction integrity and muscle wasting.
Blinding efforts:
Study Location:
University of New Mexico School of Medicine and New Mexico Veterans Affairs Health Care System
Source(s) of Funding:
Not-for-profit, Government, University/Hospital
Please specify names of funders:
National Institutes of Health, Department of Veterans Affairs, New Mexico VA Health Care System, Michael E. DeBakey VA Medical Center, Alkek Foundation