AWM: Adults with Overweight or Obesity BMI >25 (2020-21)

Author and Year:
Georgoulis M, Yiannakouris N, et al, 2020
PubMed ID:
Article Title:
Cardiometabolic Benefits of a Weight Loss Mediterranean Diet/Lifestyle Intervention in Patients with Obstructive Sleep Apnea: The "MIMOSA" Randomized Clinical Trial
Georgoulis M, Yiannakouris N, Kechribari I, Lamprou K, Perraki E, Vagiakis E, Kontogianni M
Year of publication:
Page numbers:
Study Design:
Randomized Controlled Trial
Risk of Bias Assessment Rating:
Some concerns
Inclusion Criteria:
Adult (18-65 years old), overweight or obese (BMI >/= 25 kg/m2) and had moderate or severe OSA (apnea hypopnea index (AHI) >/= 15 events/hour of sleep
Exclusion Criteria:
Presence of central sleep apnea or other sleep disorders, such as narcolepsy, restless legs syndrome and chronic pain syndrome, presence of chronic diseases such as diabetes mellitus, cardiovascular disease, familial dyslipidemia, severe uncontrolled hypertension (systolic/diastolic blood pressure > 160/95 mm HG), chronic kidney disease, malignancy, inflammatory diseases and psychiatric disorders, hospitalization due to acute or chronic respiratory disease or required use of supplemental oxygen during the last year, any kind of surgery during the last three months, pregnancy or breastfeeding for women, use of antipsychotic, antidepressant and hypnotic drugs, systemic use of steroids or hormone replacement therapy for women, habitual excessive alcohol intake (>210 and >140 g of alcohol for men and women, respectively, and currently on a weight loss diet or recent change in lifestyle habits.
Research Purpose:
To explore whether the addition of a weight loss Mediterranean diet/lifestyle intervention to the current standard care for OSA in clinical practice (i.e. CPAP prescription and brief written healthy lifestyle advice) has an incremental beneficial effect on OSA patients cardiometabolic profile i.e. MS prevalence, glucose metabolic indices, lipidemic profile parameters, liver enzymes and blood pressure, over the effect of standard care alone.
Blinding efforts:
Study Location:
Evangelismos Hospital, Athens, Greec
Source(s) of Funding:
Please specify names of funders:
Postgraduate Program "Applied Nutrition & Dietetics" Department of Nutrition and Dietetics, School of Health & Education, Harokopio University, Athens, Greece