Chronic Kidney Disease

CKD: Calcium (2018)

• Intervention
  What is the effect of calcium intake on electrolyte levels in adults with CKD 1-5D and post-transplant?

  • Conclusion

    In CKD pre-dialysis patients, greater oral calcium intake was associated with positive calcium balances in two studies, while one study did not observe any significant effects on ionized calcium levels. Serum calcium and phosphorus levels were unaffected by increased calcium intake, and effects on vitamin D and parathyroid hormone status showed conflicting results.

  • Grade: III
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: What is the effect of calcium intake on electrolyte levels in adults with CKD 1-5D and post-transplant?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Hill K, Martin B, Wastney M, McCabe G, Moe S, Weaver C, Peacock M. Oral calcium carbonate affects calcium but not phosphorus balance in stage 3-4 chronic kidney disease. Kidney International 2013; 83:959-66
      • Martinez I, Saracho R, Montenegro J, Llach F. The importance of dietary calcium and phosphorous in the secondary hyperparathyroidism of patients with early renal failure. American Journal of Kidney Diseases : the official journal of the National Kidney Foundation 1997; 29:496-502
      • Spiegel D, Brady K. Calcium balance in normal individuals and in patients with chronic kidney disease on low- and high-calcium diets. Kidney International 2012; 81:1116-22
  • Search Plan and Results: CKD: Electrolytes: Calcium (2018)