Chronic Kidney Disease

CKD: Vitamin K (2018)

• Intervention
  What is the effect of vitamin K supplementation on vitamin K levels in adults with CKD 1-5D and post-transplant?

  • Conclusion

    Vitamin K supplementation increased vitamin K levels in hemodialysis patients in a dose-dependent manner.

  • Grade: III
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: What is the effect of vitamin K supplementation on vitamin K levels in adults with CKD 1-5D and post-transplant?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Westenfeld R, Krueger T, Schlieper G, Cranenburg E, Magdeleyns E, Heidenreich S, Holzmann S, Vermeer C, Jahnen-Dechent W, Ketteler M, Floege J, Schurgers L. Effect of vitamin K2 supplementation on functional vitamin K deficiency in hemodialysis patients: a randomized trial. American Journal of Kidney Diseases : the official journal of the National Kidney Foundation 2012; 59:186-95
  • Search Plan and Results: CKD: Micronutrients: Vitamin K (2018)
     
  What is the effect of vitamin K supplementation on dephosphorylated-uncarboxylated MGP levels in adults with CKD 1-5D and post-transplant?

  • Conclusion

    There was a steady dose-dependent decrease of dephosphorylated-uncarboxylated MGP plasma levels according to vitamin K supplementation.

  • Grade: III
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: What is the effect of vitamin K supplementation on dephosphorylated-uncarboxylated MGP levels in adults with CKD 1-5D and post-transplant?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Westenfeld R, Krueger T, Schlieper G, Cranenburg E, Magdeleyns E, Heidenreich S, Holzmann S, Vermeer C, Jahnen-Dechent W, Ketteler M, Floege J, Schurgers L. Effect of vitamin K2 supplementation on functional vitamin K deficiency in hemodialysis patients: a randomized trial. American Journal of Kidney Diseases : the official journal of the National Kidney Foundation 2012; 59:186-95
  • Search Plan and Results: CKD: Micronutrients: Vitamin K (2018)