Chronic Kidney Disease

CKD: Zinc (2018)

Intervention
What is the effect of zinc supplementation on homocysteine levels in adults with CKD 1-5D and post-transplant?
- Conclusion
  There was no effect of 50 mg per day zinc supplementation for six weeks on homocysteine levels, but results were limited.
- Grade: II
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: What is the effect of zinc supplementation on homocysteine levels in adults with CKD 1-5D and post-transplant?
- Search Plan and Results: CKD: Micronutrients: Zinc (2018)
What is the effect of zinc supplementation on HDL cholesterol levels in adults with CKD 1-5D and post-transplant?
- Conclusion
  There was no effect of zinc supplementation on high-density lipoprotein (HDL) levels.
- Grade: II
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: What is the effect of zinc supplementation on HDL cholesterol levels in adults with CKD 1-5D and post-transplant?
- Search Plan and Results: CKD: Micronutrients: Zinc (2018)
What is the effect of zinc supplementation on total and LDL cholesterol and triglyceride levels in adults with CKD 1-5D and post-transplant?
- Conclusion
  Zinc supplementation of 50-100 mg per day may increase total cholesterol levels by a mean of 26.2 mg/dL and the effects of zinc supplementation on low-density lipoprotein (LDL) levels were unclear. There was no effect of zinc supplementation on triglyceride levels.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: What is the effect of zinc supplementation on total and LDL cholesterol and triglyceride levels in adults with CKD 1-5D and post-transplant?
- Search Plan and Results: CKD: Micronutrients: Zinc (2018)
What is the effect of zinc supplementation on zinc levels in adults with CKD 1-5D and post-transplant?
- Conclusion
  Zinc supplementation in doses of 2.2-112 mg did increase zinc levels, but did not change the proportion of participants with low zinc status.
- Grade: II
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: What is the effect of zinc supplementation on zinc levels in adults with CKD 1-5D and post-transplant?
- Search Plan and Results: CKD: Micronutrients: Zinc (2018)
What is the effect of zinc supplementation on BMI in adults with CKD 1-5D and post-transplant?
- Conclusion
  The evidence regarding the effects of zinc supplementation on BMI were mixed and limited.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: What is the effect of zinc supplementation on BMI in adults with CKD 1-5D and post-transplant?
- Search Plan and Results: CKD: Micronutrients: Zinc (2018)
What is the effect of zinc supplementation on CRP levels in adults with CKD 1-5D and post-transplant?
- Conclusion
  In zinc deficient CKD participants, findings regarding the effect of zinc supplementation on inflammatory marker levels were limited and unclear.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: What is the effect of zinc supplementation on inflammatory marker levels in adults with CKD 1-5D and post-transplant?
- Search Plan and Results: CKD: Micronutrients: Zinc (2018)
What is the effect of zinc supplementation on nutritional status indicators in adults with CKD 1-5D and post-transplant?
- Conclusion
  Zinc supplementation increased albumin levels and PNA/PCR.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: What is the effect of zinc supplementation on nutritional status indicators in adults with CKD 1-5D and post-transplant?
- Search Plan and Results: CKD: Micronutrients: Zinc (2018)