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Energy Expenditure

EE: Table 5. Medication Effects on RMR (2006)

Table 5.  Medication Effects on Resting Metabolic Rate

The evidence analysis examining factors suspected to influence RMR included a review of medications. They were classified into five categories: central nervous system, autonomic, cardiovascular, endocrine and metabolic and anti-neoplastic agents (9). It is important to note that other medications within the same drug classes as those listed below may have the same impact on RMR; however, these were either not reported in the literature or did not meet the sorting criteria for inclusion in the analysis. Further, in some cases individual medications had an impact on RMR and, in other cases, combinations of medications impacted RMR. It is recommended that a physician or pharmacist be consulted for other or similar medications and their impact on RMR. 

Central Nervous System 

Decreased RMR

Increased RMR

No RMR  impact

Fluoxetine

None noted

Alfentanil

Ibuprofen

 

Carbamazepine

Midazolam

 

Sibutramine

Midazolam + Buprenorphine

 

 

Midazolam + Fentanyl 

 

 

Midazolam +Fentanyl + Atracurium or Vecuronium

 

 

Midazolam + Morphine

 

 

Pentobarbital

 

 

Thiopental

 

 

 

 

 

Autonomic

Decreased RMR

Increased RMR

No RMR impact

Midazolam + Morphine

None noted

None noted

Pancuronium

 

 

Vecuronium

 

 

 

 

 

Cardiovascular

Decreased RMR

Increased RMR

No RMR impact

Propranolol

None noted

None noted

Atenolol

 

 

 

 

 

Endocrine and Metabolic 

Levothyroxine

Change in RMR inversely related to thyroid stimulating hormone (TSH) concentration

Glipizide

Decreased RMR when compared with Metformin

rhGH

Increased RMR in persons with growth hormone deficiency

 

 

Anti-neoplastic

Decreased RMR

Increased RMR

No RMR impact

Doxorubicin + Cyclophosphamide + Vindesine +Bleomycin + Prednisone + Methotrexate

None noted

None noted

Doxorubicin + Cyclophosphamide + Fluorouracil + Methotrexate

 

 

Zorubicin + Vincristine