EE: Table 5. Medication Effects on RMR (2006)
Table 5. Medication Effects on Resting Metabolic Rate
The evidence analysis examining factors suspected to influence RMR included a review of medications. They were classified into five categories: central nervous system, autonomic, cardiovascular, endocrine and metabolic and anti-neoplastic agents (9). It is important to note that other medications within the same drug classes as those listed below may have the same impact on RMR; however, these were either not reported in the literature or did not meet the sorting criteria for inclusion in the analysis. Further, in some cases individual medications had an impact on RMR and, in other cases, combinations of medications impacted RMR. It is recommended that a physician or pharmacist be consulted for other or similar medications and their impact on RMR.
Central Nervous System
Decreased RMR |
Increased RMR |
No RMR impact |
Fluoxetine |
None noted |
Alfentanil |
Ibuprofen |
|
Carbamazepine |
Midazolam |
|
Sibutramine |
Midazolam + Buprenorphine |
|
|
Midazolam + Fentanyl |
|
|
Midazolam +Fentanyl + Atracurium or Vecuronium |
|
|
Midazolam + Morphine |
|
|
Pentobarbital |
|
|
Thiopental |
|
|
|
|
|
Autonomic
Decreased RMR |
Increased RMR |
No RMR impact |
Midazolam + Morphine |
None noted |
None noted |
Pancuronium |
|
|
Vecuronium |
|
|
|
|
|
Cardiovascular
Decreased RMR |
Increased RMR |
No RMR impact |
Propranolol |
None noted |
None noted |
Atenolol |
|
|
|
|
|
Endocrine and Metabolic
Levothyroxine |
Change in RMR inversely related to thyroid stimulating hormone (TSH) concentration |
Glipizide |
Decreased RMR when compared with Metformin |
rhGH |
Increased RMR in persons with growth hormone deficiency |
|
|
Anti-neoplastic
Decreased RMR |
Increased RMR |
No RMR impact |
Doxorubicin + Cyclophosphamide + Vindesine +Bleomycin + Prednisone + Methotrexate |
None noted |
None noted |
Doxorubicin + Cyclophosphamide + Fluorouracil + Methotrexate |
|
|
Zorubicin + Vincristine |
|
|