DLM: Homocysteine, Folate, B-12 (2001)
The ADA 2001 Hyperlipidemia MNT Evidence-based guide for practice was originally published in a compact disk (CD) format. This 2001 project was published to the online Evidence Analysis Library for the benefit of ADA members, even though it does not follow the current online format and may be missing some of the components (all of the components of current evidence analysis include: question, conclusion, grade, search plan and results, evidence summary, overview table, worksheets, and quality check lists.)
This project was updated. Click here to view the online ADA Disorders of Lipid Metabolism Evidence-based Nutrition Practice Guideline that was published to the ADA Evidence Analysis Library in August 2005.
Homocysteine, Folate, B-12 (Hyperlipidemia 2001)
Observational studies (cohort, case control, population) show an inverse relationship between serum homosysteine and the incidence of coronary heart disease (CHD). Studies show that low folate levels and high homosysteine levels are associated with an increased incidence of CHD, whereas high serum folate and low homoscysteine levels are not associated with an increase in CHD. No experimental (Randomized Control Trials) have been done to determine the effects of folate supplementation on incidence of CHD.
This information is from the 2001 Hyperlipidemia project.
Evidence Summary: Homocysteine, Folate, B-12 (Hyperlipidemia 2001)
- Quality Rating Summary
For a summary of the Quality Rating results, click here.
- Bunout D, Garrido A, Suazo M, Kauffman R, Venegas P, de la Maza P, Petermann M, Hirsch S. Effects of supplementation with folic acid and antioxidant vitamins on homocysteine levels and LDL oxidation in coronary patients. Nutr. 2000
- Fallon UB, Ben-Shlomo Y, Elwood P, Ubbink JB, Smith GD. Caerphilly cohort study. Heart. 2001;85:153-158.
- Fallon UB, Elwood P, Ben-Shiomo Y, Ubbiank JB, Greenwood R, Smith GD. Homocysteine and ischaemic stroke in men: the Caerphilly study. J Epidemiol Commun Health. 2001
- Graham IM, Daly LE, Refsum HM, Robinson K, Brattstrom LE, et al. Plasma homocysteine as a risk factor for vascular disease. JAMA. 1997
- Mason J, Selhub J. Disease prevention: Broadening the definition of folate nutrition. Nutr in Clin Care. 1999
- Morris MS, Jacques PF, Rosenberg IH, Selhub J, Bowman BA, Gunter EW, Wright JD, Johnson CL. Serum total homocysteine concentration is related to self-reported heart attack or stroke history among men and women in the NHANES III. J Nutr. 2000.
- Morrison HI, Douglas S, Desmeules M, Wigle D. Serum folate and the risk of fatal coronary heart disease. JAMA. 1996
- Nygard O, Nordrehaug JE, Refsum H, Ueland PM, Farstad M, Vollset SE. Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med.1997; 337 (4): 230-236.
- Rimm EB, Willett WC, Hu FB, Sampson L, Colditz GA, Manson JE, Hennekens C, Stampfer MJ. Folate and vitamin B-6 from diet and supplements in relation to risk of coronary heart disease among women. JAMA. 1998 Feb 4; 279 (5): 359-364.
- Selhub J, Jacques PF, Wilson PW, Rush D, Rosenberg IH. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA. 1993