Disorders of Lipid Metabolism

DLM-SF: All-Cause Mortality (2021)

• Intervention
  In adults with or without cardiovascular disease, what is the association between the amount of saturated fat intake and all-cause mortality?

  • Conclusion

    In adults with and without existing cardiovascular disease, moderate quality evidence found little to no effect of reducing saturated fat intake on all-cause mortality.

  • Grade: Moderate (B)
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: In adults with or without cardiovascular disease, what is the association between the amount of saturated fat intake and all-cause mortality?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • de Souza R, Mente A, Maroleanu A, Cozma A, Ha V, Kishibe T, Uleryk E, Budylowski P, Schünemann H, Beyene J, Anand S. Intake of saturated and trans-unsaturated fatty acids and risk of all cause mortality, cardiovascular disease, and type 2 diabetes: systematic review and meta-analysis of observational studies. BMJ (Clinical Research Ed.) 2015; 351:h3978
      • Harcombe Z, Baker J, Cooper S, Davies B, Sculthorpe N, DiNicolantonio J, Grace F. Evidence from randomised controlled trials did not support the introduction of dietary fat guidelines in 1977 and 1983: a systematic review and meta-analysis. Open Heart 2015; 2:e000196
      • Hooper L, Martin N, Jimoh O, Kirk C, Foster E, Abdelhamid A. Reduction in saturated fat intake for cardiovascular disease. Cochrane Database of Systematic Reviews 2020; 5:CD011737
  • Search Plan and Results: DLM-SF: Replacement of Saturated Fat (2021)