Disorders of Lipid Metabolism

DLM-SF: Cardiovascular Events (2021)

• Intervention
  In adults with or without cardiovascular disease, what is the association between amount of saturated fat intake and combined cardiovascular events?

  • Conclusion

    In adults with and without existing cardiovascular disease, moderate quality evidence suggests that reducing saturated fat intake may reduce cardiovascular (CV) events. Greater reduction in serum total cholesterol levels leads to a greater reduction in CV events.

  • Grade: Moderate (B)
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: In adults, with or without cardiovascular disease, what is the association between amount of saturated fat intake and combined cardiovascular events?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Hooper L, Martin N, Jimoh O, Kirk C, Foster E, Abdelhamid A. Reduction in saturated fat intake for cardiovascular disease. Cochrane Database of Systematic Reviews 2020; 5:CD011737
  • Search Plan and Results: DLM-SF: Replacement of Saturated Fat (2021)