Disorders of Lipid Metabolism

DLM-SF: Endothelial Function (2021)

• Intervention
  In adults with atherosclerotic cardiovascular disease, what is the effect of the amount of saturated fat intake on endothelial function?

  • Conclusion

    No studies were identified that evaluated effect of saturated fat intake on endothelial function in adults with atherosclerotic cardiovascular disease.

  • Grade: V
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Search Plan and Results: DLM-SF: Endothelial Function and Inflammation (2021)
     
  In adults with risk factors for atherosclerotic cardiovascular disease, what is the effect of the amount of saturated fat intake on endothelial function?

  • Conclusion

    In adults with risk factors for atherosclerotic cardiovascular disease, it is unclear if reduced intake of saturated fat replaced with monounsaturated fat or carbohydrates improves endothelial function, based on limited evidence and high heterogeneity (I²=96%).

  • Grade: Very Low (D)
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: In adults with risk factors for atherosclerotic cardiovascular disease, what is the effect of the amount of saturated fat intake on endothelial function?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Fuentes F, López-Miranda J, Sánchez E, Sánchez F, Paez J, Paz-Rojas E, Marín C, Gómez P, Jimenez-Perepérez J, Ordovás J, Pérez-Jiménez F. Mediterranean and low-fat diets improve endothelial function in hypercholesterolemic men. Annals of Internal Medicine 2001; 134:1115-1119
      • Perez-Martinez P, Moreno-Conde M, Cruz-Teno C, Ruano J, Fuentes F, Delgado-Lista J, Garcia-Rios A, Marin C, Gomez-Luna M, Perez-Jimenez F, Roche H, Lopez-Miranda J. Dietary fat differentially influences regulatory endothelial function during the postprandial state in patients with metabolic syndrome: from the LIPGENE study. Atherosclerosis 2010; 209:533-538
      • Sanders TAB, Lewis FJ, Goff LM, Chowienczyk PJ. SFAs do not impair endothelial function and arterial stiffness. American Journal of Clinical Nutrition 2013; 98:677-683
  • Search Plan and Results: DLM-SF: Endothelial Function and Inflammation (2021)
     
  In healthy adults, what is the effect of the amount of saturated fat intake on endothelial function?

  • Conclusion

    The effect of amount of saturated fat intake on endothelial function in healthy adults is uncertain due to limited available evidence.

  • Grade: Very Low (D)
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: In healthy adults, what is the effect of the amount of saturated fat intake on endothelial outcomes?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Fuentes F, López-Miranda J, Pérez-Martínez P, Jiménez Y, Marín C, Gómez P, Fernández J, Caballero J, Delgado-Lista J, Pérez-Jiménez F. Chronic effects of a high-fat diet enriched with virgin olive oil and a low-fat diet enriched with alpha-linolenic acid on postprandial endothelial function in healthy men. British Journal of Nutrition 2008; 100:159-165
      • Marin C, Ramirez R, Delgado-Lista, J, Yubero-Serrano EM, Perez-Martinez P, Carracedo J, Garcia-Rios A, Rodriguez F, Gutierrez-Mariscal RM, Gomez P, Perez-Jimenez F, Lopez-Miranda J. Mediterranean diet reduces endothelial damage and improves the regenerative capacity of endothelium. American Journal of Clinical Nutrition 2011; 93:267-274
  • Search Plan and Results: DLM-SF: Endothelial Function and Inflammation (2021)