Disorders of Lipid Metabolism

DLM-SF: Cardiovascular Disease Mortality (2021)

• Intervention
  In adults with or without cardiovascular disease, what is the association between amount of saturated fat intake and cardiovascular disease mortality?

  • Conclusion

    In adults with and without existing cardiovascular disease, moderate quality evidence found little or no effect of reducing saturated fat intake on cardiovascular disease mortality.

  • Grade: Moderate (B)
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: In adults with or without cardiovascular disease,what is the association between amount of saturated fat intake and cardiovascular disease mortality?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • de Souza R, Mente A, Maroleanu A, Cozma A, Ha V, Kishibe T, Uleryk E, Budylowski P, Schünemann H, Beyene J, Anand S. Intake of saturated and trans-unsaturated fatty acids and risk of all cause mortality, cardiovascular disease, and type 2 diabetes: systematic review and meta-analysis of observational studies. BMJ (Clinical Research Ed.) 2015; 351:h3978
      • Hooper L, Martin N, Jimoh O, Kirk C, Foster E, Abdelhamid A. Reduction in saturated fat intake for cardiovascular disease. Cochrane Database of Systematic Reviews 2020; 5:CD011737
  • Search Plan and Results: DLM-SF: Replacement of Saturated Fat (2021)