DLM: Stanols/Sterols (2001)
The ADA 2001 Hyperlipidemia MNT Evidence-based guide for practice was originally published in a compact disk (CD) format. This 2001 project was published to the online Evidence Analysis Library for the benefit of ADA members, even though it does not follow the current online format and may be missing some of the components (all of the components of current evidence analysis include: question, conclusion, grade, search plan and results, evidence summary, overview table, worksheets, and quality check lists.)
Stanols/Sterols (Hyperlipidemia 2001)
Plant stanol/sterol esters are effective in lowering serum total cholesterol and LDL cholesterol in both healthy adults and in women with coronary heart disease (CHD). A reduction of up to 10% total cholesterol is observed when 2-3 g of plant stanol/sterol esters are consumed daily. There is a dose response in serum cholesterol with a daily consumption of 1.6 to 3.2 g plant stanol/sterol esters.
This information is from the 2001 Hyperlipidemia project.
- Grade I means there is Good/Strong evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited/Weak;
- Grade IV is Expert Opinion Only;
- Grade V is Not Assignable.
Evidence Summary: Stanols/Sterols (Hyperlipidemia 2001)
- Quality Rating Summary
For a summary of the Quality Rating results, click here.
- Gylling H, Radhakrishnan R, Miettinin TA. Reduction of serum cholesterol in postmenopausal women with previous myocardial infarction and cholesterol malabsorption induced by dietary sitostanol ester margarine: women and dietary sitostanol. Circulation;1997;96:4226-4231
- Hallikainen MA, Sarkkinen ES, Uusitupa MI. Plant stanol esters affect serum cholesterol concentrations of hypercholesterolemic men and women in a dose-dependent manner. J Nutrition. 2000;130:767-776.
- Lichtenstein AH, Deckelbaum RJ. Stanol/Sterol ester-containing foods and blood cholesterol levels. Circulation. 2001;103:1177-1179.
- Miettinen TA, Puska P, Gylling H, Vanhanen H, Vartiainen E. Reduction of serum cholesterol with sitostanol-ester margarine in a mildly hypercholesterolemic population. N Engl J Med. 1995; 333: 1,308-1,312.