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  • Intervention
    In adults, what is the relationship between supplemental vitamin E and plasma lipid levels?
    • Conclusion

      Supplemental vitamin E given both in natural and synthetic forms does not have a beneficial effect on serum lipids. Study doses varied and were reported to be between 30mg and 1,000mg per day or 400 IU to 3,200 IU per day, alone or in combination with other antioxidants.

      * For information on converting mg to IU, see Vitamin E Equivalents.

    • Grade: I
      • Grade I means there is Good/Strong evidence supporting the statement;
      • Grade II is Fair;
      • Grade III is Limited/Weak;
      • Grade IV is Expert Opinion Only;
      • Grade V is Not Assignable.
      • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
      • Moderate (B) means we are moderately confident in the effect estimate;
      • Low (C) means our confidence in the effect estimate is limited;
      • Very Low (D) means we have very little confidence in the effect estimate.
      • Ungraded means a grade is not assignable.
    In adults, what is the relationship between supplemental vitamin E and incidence of non-fatal MI and non-fatal stroke?
    • Conclusion

      Supplemental vitamin E given both in natural and synthetic forms does not decrease the incidence of non-fatal MI or stroke in patients with and without a history of CVD. Study doses varied and were reported to be between 30mg and 1,000mg per day or 400 IU to 3,200 IU per day.

      *For information on converting mg to IU, see Vitamin E Equivalents.

    • Grade: I
      • Grade I means there is Good/Strong evidence supporting the statement;
      • Grade II is Fair;
      • Grade III is Limited/Weak;
      • Grade IV is Expert Opinion Only;
      • Grade V is Not Assignable.
      • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
      • Moderate (B) means we are moderately confident in the effect estimate;
      • Low (C) means our confidence in the effect estimate is limited;
      • Very Low (D) means we have very little confidence in the effect estimate.
      • Ungraded means a grade is not assignable.
    • Search Plan and Results: Antioxidants (Beta-Carotene, Vitamin C and Vitamin E) and Cardiovascular Disease 2008
       
    In adults, what is the relationship between supplemental vitamin E and cardiovascular disease mortality (from MI and stroke)?
    • Conclusion

      Supplemental vitamin E given both in natural and synthetic forms does not decrease the risk of cardiovascular death due to MI or stroke in patients with and without a history of CVD. Study doses varied and were reported to be between 30 mg and 1,000 mg per day or 400 IU to 3,200 IU per day. 

      *For information on converting mg to IU, see Vitamin E Equivalents.

    • Grade: I
      • Grade I means there is Good/Strong evidence supporting the statement;
      • Grade II is Fair;
      • Grade III is Limited/Weak;
      • Grade IV is Expert Opinion Only;
      • Grade V is Not Assignable.
      • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
      • Moderate (B) means we are moderately confident in the effect estimate;
      • Low (C) means our confidence in the effect estimate is limited;
      • Very Low (D) means we have very little confidence in the effect estimate.
      • Ungraded means a grade is not assignable.